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In consequence, with the thrombocytopenia and haemorrhage, the expected lack of NO-suppression of platelet aggregation [33], the acceleration and amplification of the induced pattern of platelet activation resulting in platelet exhaustion [9] (L-NAME), grossly correspond to the suggested inhibition of platelet aggregation, by direct action on an intraplatelet constitutive calcium-dependent NOS [3335] (L-arginine)

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Giuffr M, Moretti R, Campisciano G, da Silveira ABM, Monda VM, Comar M, Di Bella S, Antonello RM, Luzzati R, Croc LS

Examples of epigenetic mechanisms may be mentioned as DNA methylation and histone acetylation [3]

doi: 10.1046/j.1468-2982.1995.015002094.x 78

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